Clinical Study on the Effect of Physical Activity on Cognition and Memory in the Elderly
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Aerobic Exercise
- Sponsor
- University Hospital Muenster
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition
- Last Updated
- 13 years ago
Overview
Brief Summary
Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.
Investigators
Eligibility Criteria
Inclusion Criteria
- •50-80 years old
- •lesser activity
Exclusion Criteria
- •regular physical activity
- •heavy smoking, drinking,
- •BMI \< 20
- •MMSE \< 25
Outcomes
Primary Outcomes
Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition
Time Frame: 6 months
Change of delayed memory scores in #of words in a Verbal learning task after 6 months of intervention/control condition
Time Frame: 6 months
Change of performance in ms in a reaction time task after 6 months of intervention/control condition
Time Frame: 6 months
Change of relative regional grey matter volumes in % measured by T1-weighted MRI after 6 months of intervention/control condition
Time Frame: 6 months
Secondary Outcomes
- Change of physical measurements (ECG)/fitness assessments (lactate) after 6 months of intervention/control condition(6 months)
- Change of BDNF blood serum levels in ng/dl after 6 months of intervention/control condition(6 months)