PULMONARY REHABILITATION TO REDUCE POST-TUBERCULOSIS MORBIDITY (TB PURE)-A RANDOMISED MULTI-CENTRE TRIAL - TB PURE

S National Institutes of Health0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年9月18日

研究概览

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•Microbiologically confirmed (smear microscopy, GeneXpert or culture) pulmonary TB disease.Participants with just smear microscopy results will be enrolled provisionally to stay within the window of enrollment. Thereafter, if the culture results indicate drug resistance, the participant will be offered the opportunity to participate in follow-up visits, can continue with the intervention, but the data will not be considered in the final analysis.
•Not completed more than 2 weeks of TB treatment
•Receiving TB care at the outpatient clinics at the TB PuRe study sites
•Willingness to complete 48 weeks of study evaluations.
•Access to a smartphone.

•Modified Medical Research Council score of 0 points (dyspnea only with strenuous exercise)
•Multi or extensively drug-resistant TB disease.
•Extrapulmonary TB disease at any clinical sites without pulmonary involvement
•TB meningitis or TB of the spine
•Symptomatic cardiovascular disease, including coronary artery disease, arrhythmias and congestive cardiac failure.
•Karnofsky Score < 40 points
•Any medical condition that prevents pulmonary rehabilitation eg: fracture of lower/upper limbs/pregnancy
•Bronchodilators and/or corticosteroids inhaled or otherwise.

发起方

S National Institutes of Health