Comparison of clinical outcomes between polyvalent and monovalent antivenoms: a pilot study

Phase 2

• Conditions: Snakebite patients requiring antivenoms; Snakebite; Antivenom; Polyvalent; Monovalent; The Thai Red Cross Society

• Registration Number: TCTR20210826004
• Lead Sponsor: King Chulalongkorn Memorial Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-26
• Study Completion: 2022-08-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Patients older than 7 years old who are bitten by snakes and present to King Chulalongkorn Memorial Hospital (KCMH) from 1 September 2021 to 31 August 2022 (or after IRB approval).
2. Antivenom therapy is indicated

Exclusion Criteria

1. The patient is not registered in the KCMH database
2. The bite is confirmed to be from animals other than snakes
3. The patient does not consent to participate in the research
4. The patient is allergic to horse-derived products
5. The patient has a history of systemic corticosteroid use or receive medications that might interfere with the study (upon investigators consideration) 4 weeks before the bite

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Efficacy - local effect at day 0, 1, 3, 7 after bite limb circumference,Efficacy - hematotoxic effect at day 0, 1, 3, 7 after bite INR, 20min WBCT, platelet, fibrinogen,Efficacy - neurotoxic effect at day 0, 1, 3, 7 after bite motor strength,Efficacy at day 7 after bite mortality

Secondary Outcome Measures

Name	Time	Method
Side effect at 0, 30 min, 60 min, 2 h, after antivenom and day 7 after bite anaphylactic symptoms