Tagraxofusp in Patients With CD123+ or With BPDCN-IPh-like Acute Myeloid Leukemia

Phase 2

Terminated

• Conditions: Acute Myeloid Leukemia
• Interventions: Drug: tagraxofusp

• Registration Number: NCT04342962
• Lead Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto

Brief Summary

Non-randomized, open-label, multicenter phase II Study for the treatment of

* 25 R/R BPDCN-IF (CD123/CD4/CD56 positive) AML patients and

* 25 patients presenting R/R AML CD123+, but negative for either, or both, CD4 and CD56.

Patients will be treated with 12 mcg/kg/day of tagraxofusp for 5 days, for at least 4 cicles.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-04-09
• Study First Submitted QC: 2020-04-10
• Study First Posted: 2020-04-13
• Study Start: 2021-02-16
• Primary Completion: 2024-01-18
• Study Completion: 2024-01-18
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-28
• Last Update Posted: 2025-01-30

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• The patient has evidence of AML in the peripheral blood and/or bone marrow with either BPDCN-IF [CD123/CD4/CD56 (+)] or with AML that is CD123+ but negative for either, or both, CD4 and CD56.

• The patient is ≥18 years old.

• The patient must be refractory to at least one previous line of conventional therapy (either high dose therapy or hypomethylating agents) or relapsed after receiving conventional therapy (a maximum of two previous line of therapy is admitted).

• The patient has an Eastern Cooperative Oncology Group (ECOG) performance score (PS) of 0 to 2.

• The patient has adequate baseline organ function, including cardiac, renal, and hepatic function:

  1. Left ventricular ejection fraction (LVEF) ≥institutional lower limit of normal as measured by multigated acquisition (MUGA) scan or 2-dimensional (2-D) echocardiography(ECHO) within 21 days before start of therapy and no clinically significant abnormalities on a 12-lead electrocardiogram (ECG).
  2. Serum creatinine ≤1.5 mg/dL (133 μmol/L).
  3. Serum albumin ≥3.2 g/dL (32 g/L) (albumin infusions are not permitted to enable eligibility).
  4. Bilirubin ≤1.5 mg/dL (26 μmol/L).
  5. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 times the upper limit of normal (ULN).

• If the patient is a woman of childbearing potential (WOCBP), she must have a negative serum or urine pregnancy test at screeningwithin 1 week before treatment.

• The patient has signed informed consent before initiation of any study-specific procedures or treatment.

• The patient is able to adhere to the study visit schedule and other protocol requirements, including follow-up for survival assessment.

• The patient (male and female) agrees to use acceptable contraceptive methods for the duration of time on the study and continue to use acceptable contraceptive methods for 1 week after the last infusion of tagraxofusp.

Exclusion Criteria

• The patient has a diagnosis of acute promyelocytic leukemia (APL; FAB subtype M3).
• The patient has persistent clinically significant toxicities of Grade≥2 from previous chemotherapy (excluding alopecia, nausea, fatigue, and liver function tests [as mandated in the inclusion criteria]).
• The patient has received treatment with chemotherapy, wide-field radiation, or biologic therapy within 14 days of study entry.
• The patient has received treatment with an investigational agent within 14 days of study entry.
• The patient has previously received treatment with tagraxofusp.
• The patient has an active malignancy and/or cancer history (excluding antecedent MDS) that may confound the assessment of the study endpoints. Patients with a past cancer history (within 2 years of entry) with substantial potential for recurrence and/or ongoing active malignancy will be evaluated on a case by case basis. Patients with the following neoplastic diagnoses are eligible: non-melanoma skin cancer, carcinoma in situ, cervical intraepithelial neoplasia, organ-confined prostate cancer with no evidence of progressive disease.
• The patient has clinically significant cardiovascular disease (eg, uncontrolled or any New York Heart Association Class 3 or 4 congestive heart failure, uncontrolled angina, history of myocardial infarction, unstable angina or stroke within 6 months before study entry, uncontrolled hypertension or clinically significant arrhythmias not controlled by medication).
• The patient has uncontrolled, clinically significant pulmonary disease (eg, chronic obstructive pulmonary disease, pulmonary hypertension) that, in the opinion of the Investigator, would put the patient at significant risk for pulmonary complications during the study.
• The patient has known active or suspected central nervous system (CNS) leukemia. If suspected, CNS leukemia should be ruled out with relevant imaging and/or examination of cerebrospinal fluid.
• The patient is receiving immunosuppressive therapy - with the exception of low-dose prednisone (≤10 mg/day) - for treatment or prophylaxis of graft-versus-host disease (GVHD). If the patient has been on immunosuppressive treatment or prophylaxis for GVHD, the treatment(s) must have been discontinued at least 14 days before study treatment and there must be no evidence of Grade ≥2 GVHD.
• The patient has uncontrolled intercurrent illness including, but not limited to, uncontrolled infection, disseminated intravascular coagulation, or psychiatric illness/social situations that would limit compliance with study requirements.
• The patient is pregnant or breastfeeding.
• The patient has known positive status for human immunodeficiency virus or active or chronic hepatitis B or hepatitis C (Patients with positive serology for HBV can be enrolled and must receive antiviral prophylaxis - i.e lamivudine or entcavir).
• The patient is oxygen-dependent.
• The patient has any medical condition that, in the opinion of the Investigator, places the patient at an unacceptably high risk for toxicities.
• The patient has AML and requires more than 1 g/day of hydroxyurea (Hydroxyureaispermittedatdoses of ≤1 g/day.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Experimental arm	tagraxofusp	12 mcg/kg/day of tagraxofusp for 5 days, for at least 4 cycles of therapy; each cycle is 21 days. Patients will receive the study drug until disease progression or in case of toxicity.

Primary Outcome Measures

Name	Time	Method
The objective response rate (ORR)	4 months	Evaluate the activity of tagraxofusp, in terms of ORR (PR + CR + CRi), in patients with CD123+ or BlasticPlasmacytoid Dendritic Cell Neoplasm-like phenotype (BPDCN-IF) Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML).

Secondary Outcome Measures

Name	Time	Method
Overall survival (OS)	24 months	Overall survival
Rate of AEs and SAEs	28 months	Safety analysis according to CTCAE criteria
Event Free Survival (EFS)	24 months	Event Free Survival
Cumulative incidence of relapse (CIR)	24 months from response assessment	Cumulative incidence of relapse
Percentage of patients undergoing allogeneic stem cell transplantation	12 months	in MRD-negative CR
Disease Free Survival (DFS)	24 months from response assessment	Disease Free Survival

Trial Locations

Locations (10)

Asst Degli Spedali Civili Di Brescia - Uo Ematologia; 🇮🇹 Brescia, Italy

Irccs Aou San Martino - Genova - Uo Clinica Ematologica; 🇮🇹 Genova, Italy

Aou Di Bologna - Policlinico S. Orsola-Malpighi - Uoc Ematologia; 🇮🇹 Bologna, Italy

Aou Policlinico Vittorio Emanuele, Po Ospedaliero "G. Rodolico" - Uo Ematologia Con Trapianto Di Midollo Osseo - Catania; 🇮🇹 Catania, Italy

Ao Ospedali Riuniti Villa Sofia Cervello - Palermo - Uo Ematologia Ad Indirizzo Oncologico; 🇮🇹 Palermo, Italy

Asst Papa Giovanni Xxiii - Ospedale Di Bergamo - Sc Ematologia; 🇮🇹 Bergamo, Italy

Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia; 🇮🇹 Milano, Italy

Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico - Milano - Ematologia - Padiglione Marcora; 🇮🇹 Milano, Italy

Ao Di Perugia, Ospedale S. Maria Della Misericordia - Ematologia E Trapianto Midollo Osseo; 🇮🇹 Perugia, Italy

Aou Senese - Uoc Ematologia E Trapianti; 🇮🇹 Siena, Italy