Comparison of Fractional Flow Reserve Versus Instant Wave-Free Ratio for Assessment of Coronary Artery Stenosis Severity in Routine Practice
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- NHS National Waiting Times Centre Board
- Enrollment
- 200
- Locations
- 5
- Primary Endpoint
- Comparison of Fractional Flow Reserve vs. instant Wave-Free Ratio for assessment of coronary artery stenosis severity in routine practice
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
Comparison of Fractional Flow Reserve versus instant Wave-Free Ratio for assessment of coronary artery stenosis severity in routine practice
- To compare FFR to iFR in arbitrary consecutive patients referred for percutaneous coronary intervention (PCI).
- To investigate the influence of hyperemia on iFR.
- To test reproducibility of iFR and FFR.
Investigators
Prof. Keith G. Oldroyd
Consultant Cardiologist
NHS National Waiting Times Centre Board
Eligibility Criteria
Inclusion Criteria
- •all consecutive patients undergoing FFR assessment for standard clinical indications.
Exclusion Criteria
- •prior CABG
- •extremely tortuous, calcified lesions
- •coronary artery occlusion
- •acute MI within 5 days
Outcomes
Primary Outcomes
Comparison of Fractional Flow Reserve vs. instant Wave-Free Ratio for assessment of coronary artery stenosis severity in routine practice
Time Frame: 30 days
In this prospective, multicenter, international investigation, all consecutive patients in 5 centers, referred for PCI will be included. FFR will be submitted for one vessel in each patient - this will be the first vessel in which the FFR is performed. Measurements will be performed in duplicate. iFR will be calculated for all lesions for which an FFR measurement is submitted. In addition, iFR and FFR will be compared retrospectively in 1000 patients who had FFR measurements in the recent past
Secondary Outcomes
- iFR at rest vs iFr during hyperemia(30 days)
- Repeatability of iFr and FFR(30 days)