Improving gait in hereditary spastic paraplegia: towards evidence-based and individually tailored rehabilitatio

Recruiting

Conditions: Hereditary spastic paraplegia (HSP) and Strumpell disease
10029317

Registration Number: NL-OMON48504

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 36

Inclusion Criteria

- Diagnosis of pure HSP based on molecular diagnosis (e.g. SPG-4 mutations) or
based on inheritance.
- Age between 18 and 70 years old.
- Being able to independently walk barefoot on a level ground for 50 meters
without a walking aid (use of orthopaedic devices or made-to-measure footwear
is allowed).

Exclusion Criteria

-Other neurological or serious orthopaedic or psychiatric co-morbidity as well
as previous surgical interventions of the lower extremities.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Gait adaptability, as measured with the obstacle subtask of the Emory<br /><br>Functional Ambulation Profile (EFAP).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are the number of falls and the scores on the 10<br /><br>meter walk test, 6min walk test and ladder gait test.<br /><br>In addition we will investigate whether individual improvement in gait<br /><br>adaptability as measured with the Mini-BEST test is statistically related to<br /><br>individual balance capacity, more than to lower extremity muscle strength or<br /><br>muscle tone. Furthermore, we will measure physical activity in daily life by<br /><br>wearable sensors. </p><br>