Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation
- Registration Number
- NCT04007341
- Lead Sponsor
- Seoul St. Mary's Hospital
- Brief Summary
The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- elective video-assisted thoracoscopic surgery (VATS) lobectomy
- 20 < age < 75
- American Society of Anesthesiologists (ASA) classification I~II
Exclusion Criteria
- preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)
- steroid administration within 1 month
- hematologic / autoimmune disease
- congestive heart failure (NYHA class III~IV) or significant arrhythmia
- severe obstructive / restrictive pulmonary disease
- previous history of thoracic surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dexmedetomidine group Dexmedetomidine Patients in the dexmedetomidine group were infused with a loading dose of dexmedetomidine (1.0 mcg/kg over 10 min) and were thereafter infused at a rate of 0.5 mg/kg/h.
- Primary Outcome Measures
Name Time Method Interleukin (IL)-6 24 hours after surgery Blood samples were collected from the antecubital vein
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Seoul St.Mary's Hospital
🇰🇷Seoul, Korea, Republic of