NCT04007341已完成不适用
Effect of Dexmedetomidine on the Inflammatory Response in Patients Undergoing Lung Resection Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Interleukin (IL)-6
研究概览
简要总结
The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective video-assisted thoracoscopic surgery (VATS) lobectomy
- •20 < age < 75
- •American Society of Anesthesiologists (ASA) classification I~II
排除标准
- •preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)
- •steroid administration within 1 month
- •hematologic / autoimmune disease
- •congestive heart failure (NYHA class III~IV) or significant arrhythmia
- •severe obstructive / restrictive pulmonary disease
- •previous history of thoracic surgery
研究组 & 干预措施
Dexmedetomidine group
Experimental
Patients in the dexmedetomidine group were infused with a loading dose of dexmedetomidine (1.0 mcg/kg over 10 min) and were thereafter infused at a rate of 0.5 mg/kg/h.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Interleukin (IL)-6
时间窗: 24 hours after surgery
Blood samples were collected from the antecubital vein
次要结局
未报告次要终点
研究者
Wonjung Hwang
Assistant professor
Seoul St. Mary's Hospital
研究点 (1)
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