Recovery of Carotid Body Function After Full Recovery Neuromuscular Block

Leiden University Medical Center1 site in 1 country35 target enrollmentAugust 15, 2022

ConditionsPeripheral Chemosensitivity

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Peripheral Chemosensitivity
Sponsor: Leiden University Medical Center
Enrollment: 35
Locations: 1
Primary Endpoint: Carotid body function after full recovery of neuromuscular block
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation

Registry

clinicaltrials.gov

Start Date

August 15, 2022

End Date

April 1, 2023

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Leiden University Medical Center

Responsible Party

Principal Investigator

Martijn Boon

MD PhD

Leiden University Medical Center

Eligibility Criteria

Inclusion Criteria

•\* age \> 18 years

Exclusion Criteria

•BMI index \> 30 kg/m2
•Known or suspected neuromuscular disorders impairing neuromuscular function;
•Allergies to muscle relaxants, anesthetics or narcotics;
•A (family) history of malignant hyperthermia or any other muscle disease;
•Any neurological or psychiatric illness (including a history of anxiety).
•ASA class 3 or higher
•Gastro-oesophageal regurgitation

Outcomes

Primary Outcomes

Carotid body function after full recovery of neuromuscular block

Time Frame: 40 minutes after full recovery of neuromuscular block

Carotid body function will be determined by measuring acute hypoxic ventilatory response

Secondary Outcomes

Carotid body function at symptomatic neuromuscular block(5 minutes after stable partial neuromuscular block)
Carotid body function after full recovery of neuromuscular block(40 minutes after full recovery of neuromuscular block symptoms)
Carotid body function at full recovery of NMB symptoms(0 minutes after full recovery of neuromuscular block symptoms)