NCT05149872已完成4 期
Recovery of Carotid Body Function After Full Recovery Neuromuscular Block
Leiden University Medical Center2 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2022年8月15日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Carotid body function after full recovery of neuromuscular block
研究概览
简要总结
This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •* age > 18 years
排除标准
- •BMI index > 30 kg/m2
- •Known or suspected neuromuscular disorders impairing neuromuscular function;
- •Allergies to muscle relaxants, anesthetics or narcotics;
- •A (family) history of malignant hyperthermia or any other muscle disease;
- •Any neurological or psychiatric illness (including a history of anxiety).
- •ASA class 3 or higher
- •Gastro-oesophageal regurgitation
结局指标
主要结局
Carotid body function after full recovery of neuromuscular block
时间窗: 40 minutes after full recovery of neuromuscular block
Carotid body function will be determined by measuring acute hypoxic ventilatory response
次要结局
- Carotid body function at symptomatic neuromuscular block(5 minutes after stable partial neuromuscular block)
- Carotid body function after full recovery of neuromuscular block(40 minutes after full recovery of neuromuscular block symptoms)
- Carotid body function at full recovery of NMB symptoms(0 minutes after full recovery of neuromuscular block symptoms)
研究者
Martijn Boon
MD PhD
Leiden University Medical Center
研究点 (2)
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