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临床试验/NCT05932784
NCT05932784已完成不适用

The Impact of Aortic Valve Compression During Cardio-pulmonary Resuscitation on Patients With Out-of-hospital Cardiac Arrest: A Single-center Observational Study Using Transesophageal Echocardiography

Far Eastern Memorial Hospital1 个研究点 分布在 1 个国家目标入组 76 人开始时间: 2020年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
76
试验地点
1
主要终点
sustained return of spontaneous circulation (ROSC)

研究概览

简要总结

Purpose:

This study aims to find out if the current way of performing chest compressions during resuscitation for patients who have suffered a cardiac arrest outside of the hospital is affecting their chances of recovery. Recent research suggests that more than half of these patients receive chest compressions near their aortic valve, which might block blood flow and make their condition worse. We will use a special imaging technique called transesophageal echocardiography (TEE) during resuscitation to see if compressions near the aortic valve impact patient outcomes.

Methods:

We will conduct a study with patients who have suffered a cardiac arrest outside of the hospital and are receiving TEE during resuscitation in the emergency department. Some patients will not be included in the study, such as those who recover quickly before the TEE is done, those who need other treatments before they recover, those with an unclear compression site, or those with poor or missing TEE images. We will divide the patients into two groups: those with compressions near their aortic valve and those without. We will collect information on the patients, the TEE recordings, the resuscitation process, and important time points. We will mainly look at whether the patients recover and maintain a steady heartbeat. We will also examine other factors like their carbon dioxide levels, whether they recover at all, if they survive to be admitted to the hospital, if they survive to be discharged, and if they have good brain function when they leave the hospital. We plan to have 37 patients in each group for accurate results.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients aged 20 or older who arrived at the ED with non-traumatic OHCA and underwent TEE during resuscitation

排除标准

  • Early ROSC before obtaining TEE image;
  • Insert the REBOA before ROSC;
  • Initiate ECMO flow before ROSC;
  • Cannot identify compression site on TEE;
  • Poor quality of TEE image;
  • Missing TEE image.

结局指标

主要结局

sustained return of spontaneous circulation (ROSC)

时间窗: 20 minutes after ROSC

successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes

次要结局

  • survival to discharge(6 months after ROSC)
  • discharge with favorable neurological outcomes(6 months after ROSC)
  • end-tidal carbon dioxide (EtCO2)(During resuscitation)
  • survival to admission(48 hours after ROSC)
  • Any return of spontaneous circulation (ROSC)(1 minutes after ROSC)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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