AMersfoort COhort Study on functional decline, Healthy ageing and Frailty (AMCOHF): *Identification of physical predictors for healthy ageing and early stages of frailty in people from the age of 55 years: a prospective 10-year follow-up cohort study'

Recruiting

Conditions: Kwetsbaarheid (zie s.v.p. paragraaf 6.1.1 (Primary endpoints) voor de definitie.
Frailty

Registration Number: NL-OMON55250

Lead Sponsor: SOMT University of Physiotherapy

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 3000

Inclusion Criteria

Subjects aged between 55 and 75 years, who are living independently in the city
of Amersfoort (the Netherlands) and who understand spoken and written are
eligible to participate. All participants will provide written informed
consent. After signing informed consent, each participant will first undergo a
medical screening by a physician in order to exclude any contra-indications for
participation to the test battery. Those who are non-frail at baseline (i.e.
robust on three frailty scales: score=0/5 for the Fried phenotype, score<0.25
for the Rockwood Frailty Index as operationalised by Collerton et al. and
score<4/15 for the Groningen Frailty Indicator) will be included in the
longitudinal study and invited to be reassessed for potential early markers of
frailty every 2.5 years for 10 years.

Exclusion Criteria

Subjects who are at baseline unable to participate in the assessments due to
physical (e.g. unable to stand up or walk) or cognitive impairments (e.g.
unable to understand the test instructions and/or Mini Mental State Examination
score < 23/30), will be excluded as well as those with a recent (past 6 months)
diagnosis of cancer and/or who had surgery, chemotherapy or radiotherapy within
the past 6 months or scheduled for the near future.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Variables: Factors related to trajectories of intrinsic capacity covering 7<br /><br>physiological systems. Please see sections 6.1.2.1 to 6.1.2.7 of the research<br /><br>protocol for a desription of the physiological systems, the factors and the<br /><br>measurements.<br /><br><br /><br>Primary outcome: Staying robust or the occurence of frailty when positive on at<br /><br>least one of three instruments (Fried Phenotype, Rockwood Frailty Index,<br /><br>Groningen Frailty Indicator). Please see section 6.1.1 of the research protocol<br /><br>for a description of these instruments for measuring frailty. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Additional explanatory variables: Factors related to functional ability and/or<br /><br>(neuro)physiological factors that can explain changes in trajectories of<br /><br>intrinsic capacity. Please see sections 6.1.3.1 to 6.1.3.6 of the research<br /><br>protocol for descriptions of these variables and their measurements. </p><br>