Investigation of the influence of a cold-induced moderate pain stimulus on parameters of the pupillary light reflex
- Conditions
- pupillary light relfex
- Registration Number
- DRKS00032198
- Lead Sponsor
- niklinik RWTH Aachen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 36
written consent
- Subjects with epilepsy, peripheral nerve disorders or other neurological disorders (e.g. migraine, apoplexy, cerebral hemorrhage, neurodegenerative disorders);
- Subjects with severe eye diseases (e.g. glaucoma, retinal detachment, pupillary motor disorders);
- Subjects with mental diseases;
- Subjects with metabolic diseases (e.g. diabetes mellitus);
- Subjects taking medications that affect pupillary motor function, sympathetic or parasympathetic nervous system;
- Subjects taking medications that influence the ability to react and concentrate (e.g. painkillers from level II according to WHO);
- drug and/or alcohol abuse;
- Visible head injuries or diseases in the area of the head;
- Artificial eye lenses or the absence of an eye lens;
- Pregnant, breastfeeding;
- Skin diseases or sensitivity disorders of the feet;
- Polyneuropathy;
- Severe peripheral arterial occlusive disease;
- Raynaud's syndrome;
- Subjects with syncope;
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The amplitude of the pupillary light reflex in method I is expected to be significantly reduced in the exposures to ice water (pain) compared to the baseline measurement (no pain).<br>With measurement method II, this effect is expected to disappear.
- Secondary Outcome Measures
Name Time Method Ice water exposure should result in moderate pain as measured by an NRS (numeric rating scale).