Optical Cohrence Tomography Angiography as a New Predictive Biomarker in Anatomical and Functional Recovery After Endoscopic Endonasal Pituitary Surgery: a Prospective Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pituitary Adenoma
- Sponsor
- Federico II University
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Comparison between retinal structures before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study evaluates the structural parameters, by spectral domain optical coherence tomography (OCT), retinal vessel density, using OCT angiography, and visual acuity in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve.
Detailed Description
The primary outcome was to detect the changes in visual acuity, retinal structural and vascular features at 48 hours and 1 year after Endoscopic Endonasal Approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve. The secondary outcome was to identify potential biomarker that could predict the functional recovery at 1 year follow up.
Investigators
Gilda Cennamo
Principal Investigator
Federico II University
Eligibility Criteria
Inclusion Criteria
- •age older than 40 years
- •diagnosis of pituitary adenoma
- •treatment-naïve with Endoscopic Endonasal Pituitary Surgery
- •absence of other neurological diseases
- •absence of vitreoretinal and vascular retinal diseases
Exclusion Criteria
- •age younger than 40 years
- •No diagnosis of pituitary adenoma
- •previous treatments with Endoscopic Endonasal Pituitary Surgery
- •presence of neurological diseases
- •presence of vitreoretinal and vascular retinal diseases
Outcomes
Primary Outcomes
Comparison between retinal structures before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
Time Frame: 48 hours and 1 year follow up
8 patients with pituitary adenoma compressing optic chiasm. Changes in thickness of ganglion cell complex (microns) and in thickness of retinal nerve fiber layer (microns) before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
Comparison between retinal microvasculature before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
Time Frame: 48 hours and 1 year follow up
8 patients with pituitary adenoma compressing optic chiasm. Changes in retinal vessel density (percent) in macular and papillary regions before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
Secondary Outcomes
- Correlation between retinal structures and visual acuity after Endoscopic Endonasal Pituitary Surgery(1 year follow up)
- Correlation between retinal microvasculature and visual acuity after Endoscopic Endonasal Pituitary Surgery(1 year follow up)