EVERAGING INFLAMMATION FOR PRECISION MEDICINE IN DEPRESSION - ENFORCE

Goethe Universität Frankfurt0 个研究点目标入组 530 人开始时间: 2022年6月30日最近更新: 2024年8月19日

研究概览

暂无简介。

•Patients with depression:
•Age: between 18 and 75 years
•Presence of depressive disorder without psychotic symptoms (according to ICD 10: F32.0, F32.1, F32.2, F32.3, F33.2, F33.3) or bipolar affective disorder with depressive episode (ICD: F31.3, F31.4)
•Capacity to consent
•Patients with MS:
•Inclusion criteria for patients* with MS:
•o Age between 18 and 75
•o Capacity to consent
•o If applicable, the last cortisone treatment has taken place at least 7 days ago.
•Controls:Inclusion criteria for healthy controls:
•Age: between 18 and 75 years
•Capacity to consent

•Exclusion criteria for patients with depression:
•Presence of severe neurological disease, such as multiple sclerosis. (adjusted epilepsy is allowed)
•Presence of an acute infection (pneumonia, urinary tract infection, sepsis)
•Clearly organic or substance-induced cause of depression
•Pregnancy and lactation
•Psychiatric comorbidities are allowed as long as, in the opinion of the study physician there is no impairment at testing and will be documented
•Other medical condition that, at the discretion of the physician, makes participation impossible.
•Uncontrolled thyroid disease (thyroid disease must be anamnestically stable, i.e., no change in medication has been made in the last 28 days).
•Exclusion criteria for patients with MS:
•Acute infection (per history) or tumor.
•Uncontrolled thyroid disease (thyroid disease must be anamnestically stable, i.e., no change in medication has been made in the last 28 days).
•Exclusion criteria for healthy controls:
•Presence of psychiatric illness or psychiatric illness in First-degree family members
•Severe physical illness (tumor disease, chronic/acute infectious disease, neurodegenerative disease, rheumatological disease, severe inflammation, autoimmune diseases, neurological disease)
•Pregnancy and lactation
•Uncontrolled thyroid disease (thyroid disease must be anamnestically stable, i.e., no change in medication has been made in the last 28 days).

发起方

Goethe Universität Frankfurt