Sarcopenia and Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- prevalence of sarcopenia in patients with T2D and in the control group
研究概览
简要总结
The association of diabetes mellitus type 2 (T2DM) with sarcopenia has not been adequately investigated. Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass which may affect performance.
详细描述
The relationship between DM and sarcopenia has not been extensively investigated. Skeletal muscle is the primary site of glucose deposition, and decreased muscle mass plays a role in impaired glucose metabolism in patients with insulin resistance and type 2 diabetes. Skeletal muscle resistance to insulin action appears to be the link between type 2 diabetes (T2DM) and sarcopenia. Hyperglycemia is a metabolic dysfunction which can potentially damage muscle cells. Insulin deficiency leads to marked muscle catabolism that can be reversed by exogenous insulin administration.
The metabolic disorder in diabetics may be reversible.Thus, it may be possible to restore physical ability by restoring the musculoskeletal system.Therefore, the diagnosis of sarcopenia if made can lead to interventions which may prevent the deterioration of body composition and the subsequent deterioration of quality of life. According to the results of the aforementioned studies it is still inconclusive if the metabolic disorder in diabetes may be related to sarcopenia, or sarcopenia may be a consequence of diabetes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •T2DM participants were on treatment with oral hypoglycemic agents
- •confirmation criteria of a T2DM diagnosis were glycosylated hemoglobin A1c levels ≥ 6.5% and fasting plasma glucose ≥ 126 mg/dl (7 mmol/l).
排除标准
- •history of a cerebrovascular event, a heart stent, an artificial cardiac pacemaker or other metallic implant,
- •a malignant tumor, liver disease, end stage chronic kidney disease, a thyroid disorder, carpal tunnel syndrome,
- •subjects who received special dietary supplements such as protein powder, during the last three months were excluded from the study.
结局指标
主要结局
prevalence of sarcopenia in patients with T2D and in the control group
时间窗: Up to 12 weeks
percents in different groups
Skeletal Muscle Index
时间窗: Up to 12 weeks
Appendicular Muscle Mass/Height2
次要结局
- fat mass(Up to 12 weeks)
研究者
Yannis Dionyssiotis
Post graduate student in Hellenic Open University of Greece
Dionyssiotis, Yannis, M.D.