Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers
Phase 2
Completed
- Conditions
- DNA Damage
- Interventions
- Dietary Supplement: PlaceboDietary Supplement: Noni juice
- Registration Number
- NCT01677169
- Lead Sponsor
- Tahitian Noni International, Inc.
- Brief Summary
The purpose of this study was to determine if noni juice reduces lipid hydroperoxide (LOOH) and malondialdehyde (MDA) derived-DNA adducts, markers of oxidative DNA damage, in peripheral blood lymphocytes of cigarette smokers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 317
Inclusion Criteria
- 18 to 65 years in age, smoker of more than 20 cigarettes per day, a smoking history exceeding one year, and willing to complete a one month trial.
Exclusion Criteria
- concurrent use, or use in the previous three months, of prescription medication or antioxidant vitamins
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Ingestion of 59 mL of placebo (mixture of grape and blueberry juices and natural cheese flavor) twice daily (118 mL daily total) for 30 days. 59 mL noni juice Noni juice Ingestion of 59 mL of Tahitian Noni® juice (mixture of noni juice and grape and blueberry juices) twice daily (118 mL daily total) for 30 days. 29.5 mL noni dose Noni juice Ingestion of 29.5 mL of Tahitian Noni® juice (mixture of noni juice and grape and blueberry juices) daily for 30 days.
- Primary Outcome Measures
Name Time Method LOOH and MDA-DNA adducts 1 month LOOH and MDA-DNA adducts in lymphocytes immediately prior to intervention and at completion of intervention.
- Secondary Outcome Measures
Name Time Method adverse events 1 month Adverse health events
Trial Locations
- Locations (1)
University of Illinois College of Medicine at Rockford
🇺🇸Rockford, Illinois, United States