NCT06967441RecruitingNot Applicable
Respiratory Virus Infections in Hospitalized Patients With Acute Heart Failure Syndrome: A Prospective Multi-center Observational Study
Minjae Yoon3 sites in 1 country360 target enrollmentStarted: April 7, 2025Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 360
- Locations
- 3
- Primary Endpoint
- Respiratory virus PCR detection rate
Study Overview
Brief Summary
Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.
The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adult aged 19 years or older admitted to the cardiology department with acute heart failure
- •NT-proBNP >300 pg/mL
- •Clinician judgement of possible respiratory viral infection (fever >38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5 mg/dL)
- •Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons
Exclusion Criteria
- •Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP >180mmHg or DBP >110mmHg), haemoglobin <7g/dL or AHF precipitated by medication non-adherence)
- •If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
- •If there is a clear other source of infection that can explain the fever
Outcomes
Primary Outcomes
Respiratory virus PCR detection rate
Time Frame: Within 3 days of admission
Respiratory virus PCR detection rate (especially RSV, influenza virus) in acute HF
Secondary Outcomes
- Rehospitalization(12month)
- Days of hospitalization(From admission to discharge during index hospitalization (upto 30 days))
- Rate of ICU care or ventilation(From admission to discharge during index hospitalization (upto 30 days))
- In hospital mortality(From admission to discharge during index hospitalization (upto 30 days))
- mortality(12 month)
Investigators
Minjae Yoon
Assistant professor
Seoul National University Bundang Hospital
Study Sites (3)
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