Prevalence of overactive bladder (OAB) in patients with pelvic organ prolapse (POP) and predictors of symptoms of OAB after surgical correction of POP.

Recruiting

Conditions: in women with genital prolapse
Overactive bladder symptoms in women with pelvic organ prolapse - Frequent and strong desire to void
10046828
with or without urinary incontinence
10046590
10029903

Registration Number: NL-OMON35445

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

- Female patients, age 18 or greater, with a pelvic organ prolapse POP-Q stage II to IV .
- Patient will undergo prolapse repair surgery.
- Patient understands the Dutch written and spoken language.

Exclusion Criteria

- Patients who currently use anticholinergic medication.
- Patients with neurological causes of OAB.
- Patients who are pregnant or wish to become pregnant.
- Patients with a history of cancer in the pelvic region, treated with radiotherapy or surgery.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters are the presence of bothersome OAB as measured by bladder<br /><br>diary and validated disease specific questionnaires (UDI, IIQ, ICIQ-FLUTS,<br /><br>OABSS) and the outcomes of urodynamic studies (presence of detrusor<br /><br>overactivity (DO), bladder outflow obstruction (BOO)). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are the outcomes of measurement of POP-Q, ultrasound<br /><br>assesment of bladder wall thickness (BWT) and configuration of urethra and<br /><br>bladder neck, analysis of urinary biomarkers, and the findings of cystoscopy<br /><br>(presence of trabeculation).</p><br>