Rescue Stenting for Failed Endovascular Thrombectomy in Acute Ischemic Stroke (ReSET)

Yonsei University1 site in 1 country78 target enrollmentJune 24, 2019

ConditionsAcute Ischemic Stroke Intracranial Artery Occlusion

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Ischemic Stroke
Sponsor: Yonsei University
Enrollment: 78
Locations: 1
Primary Endpoint: modified Rankin scale
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study is a prospective, open-label, multi-center, registry study, designed to show that rescue stenting is safe and effective for emergency large vessel occlusion (ELVO) patients who have mechanical thrombectomy failure. Participants with ELVO will initially underwent mechanical thrombectomy usig stent retriever, contact aspiration or both. After failure of mechanical thrombectomy, rescue stenting will be performed.

Registry

clinicaltrials.gov

Start Date

June 24, 2019

End Date

July 30, 2021

Last Updated

4 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Yonsei University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Subjects experiencing acute ischemic stroke due to large vessel occlusion (intracranial internal carotid artery and middle cerebral artery M1 segment)
•Age 19 or greater
•mRS before qualifying stroke, 0 or 1
•Baseline NIHSS score 4 or more
•CT ASPECTS \> 6 or MR ASPECTS \> 5
•Good collateral statues on CT angiogram (collateral grade by Calgary group, 4 or 5) or corresponding to DEFUSE 3 or DAWN trial on perfusion imaging.
•Onset (last-seen-well) time to femoral puncture time \< 24 hours
•Failure of mechanical thrombectomy with stent retriever, contact aspiration or both
•Subjects who received rescue stenting after failure of mechanical thrombectomy
•Anticipated life expectancy of at least 12 months

Exclusion Criteria

•Any contraindication to antiplatelet medication
•Multiple simultaneous large vessel occlusions
•Severe contrast allergy or absolute contraindication to iodinated contrast agent
•Patient has a severe or fatal combined illness that will prevent improvement of follow-up or will render the procedure unlikely to benefit the patient.