NL-OMON50393尚未招募不适用
Gut Microbiome Analysis in de Novo Parkinson's Patients - DUPARM
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 480
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •All participants:
- •- Written informed consent
- •Study group:
- •- Diagnosed Parkinson*s disease according to the UK Parkinson*s Disease Society
- •Brain Bank Criteria
- •Control group:
- •- Healthy sex- and age-matched controls, also matched according to presence and
- •severity of constipation.
排除标准
- •All participants:
- •Gastrointestinal exclusion criteria:
- •- Active or persistent primary disease of the gastrointestinal tract
- •- History of peritonitis, severe endometriosis, abdominal, intestinal or
- •urogenital fistula,
- •- Hepatobiliar or pancreatic disease (except asymptomatic cholecystolithiasis)
- •- History of abdominal or anorectal surgery, except minor surgery such as
- •uncomplicated appendectomy or cholecystectomy (>6 months ago)
- •- Severe gynaecological prolapse (grade III)
- •- Cancer and/or adjuvant treatment within the last 6 months
- •- Within the last three months: narcosis, analgosedation, endoscopic procedure
- •of the gastrointestinal tract, abdominal trauma
- •- Within the last three months: gastrointestinal tract infection, food
- •intoxication,
- •Study group:
- •- History of dopaminergic medication use
- •Control group:
- •- History of neurodegenerative disease, in particular signs of parkinsonism.
- •- Probable prodromal PD. Controls will, however, be matched according to
- •presence and severity of constipation as a possible confounder.
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