Diagnostic and Prognostic Values of Cholinesterase, Amylase, Lipase and Neutrophil-to-lymphocyte Ratio in Acute Pesticide Poisoning Cases
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Diagnostic and prognostic values of cholinesterase in acute pesticide poisoning cases
研究概览
简要总结
To estimate diagnostic levels of amylase, lipase, pseudocholinestrase and neutrophili lymphocytic ratio to different pesticide poisoning.
In addition to detect prognostic values of theses enzymes & NLR and its relation to the outcome of all pesticide poisoning.
To assess descriptive sociodemographic criteria of these poisoned cases, mode of toxicity, type of pesticide poisoning at emergency room, any other associated toxicity as well as the clinical outcome.
详细描述
Acute pesticide poisoning is a global health problem responsible for majority of deaths in poisoning cases.
There is a study estimated that about 385 million cases of unintentional acute pesticide poisoning occur annually world-wide including about 11,000 fatalities.
Thirty percent of global suicides are due to pesticide poisoning as they are of low cost and easily accessible.
Most common suicidal pesticide are classified according to WHO to organophosphorus insecticides, carbamate insecticide, and methyl parathion /or the herbicide paraquat.
. Aluminum phosphide(ALP) becomes one of the commonest causes of poisoning. It is extremely toxic after self-poisoning, with a case fatality often exceeding 70% after ingestion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any possible route of exposure to pesticides
排除标准
- •Exposure to medications or toxic chemicals other than pesticides.
- •Patients with chronic comorbidities, including liver cirrhosis, symptomatic heart failure, end stage CKD(on regular hemodialysis) and COPD.
- •Patients with gallstone history or DM
- •Recent abdominal trauma
- •Open abdominal surgery within one year ago
结局指标
主要结局
Diagnostic and prognostic values of cholinesterase in acute pesticide poisoning cases
时间窗: baseline
clinical lab result of pseudocholinesterase
diagnostic and prognostic value of amylase in acute pesticide poisoning cases
时间窗: baseline
blood level of amylase
diagnostic and prognostic value of lipase in acute pesticide poisoning cases
时间窗: baseline
blood level of lipase
diagnostic and prognostic value of neutrophil-to-lymphocyte ratio in acute pesticide poisoning case
时间窗: baseline
blood level of neutrophil-to-lymphocyte ratio
次要结局
未报告次要终点
研究者
Asmaa AbouBakr Ahmed
director
Assiut University