Prevention of Postoperative Delirium With Donepezil

Phase 4

Completed

• Conditions: Cognitively Normal Elderly Individuals

• Registration Number: NCT00220896
• Lead Sponsor: Technical University of Munich

Brief Summary

Patients undergoing hip or knee joint replacement at the age of 70 years or above who are cognitively unimpaired will receive donepezil or matching placebo before (over 5-7 days), during and after (over 7 days) surgery. The incidence of delirium will be monitored at 3 days, 7 days, and 49 days following surgery. We hypothesize that the incidence of delirium can be lowered from 20 per cent to 10 per cent by the intervention.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2005-09-14
• Study First Submitted QC: 2005-09-14
• Study First Posted: 2005-09-22
• Study Start: 2006-01
• Study Completion: 2009-03
• Status Verified: 2011-09
• Last Update Submitted: 2011-09-13
• Last Update Posted: 2011-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Cognitively healthy, elective hip or knee replacement

Exclusion Criteria

• Ongoing cholinergic treatment, dementia, delirium, acute physical illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Incidence of delirium

Secondary Outcome Measures

Name	Time	Method
Cognitive performance

Trial Locations

Locations (1)

Deps. of Psychiatry and Anaesthesiology, Tech. Universitaet Munich; 🇩🇪 Munich, Germany