Periodontitis in Young Individuals, Follow up of Treatment and Disease Progression Over 10 Years
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 471
- 试验地点
- 1
- 主要终点
- Periodontal disease progression in young individuals with periodontitis 10-13 years after baseline
研究概览
简要总结
The general aim of this project is to get a better understanding how periodontitis develop in young individuals over time and identify factors that contribute to disease recurrence. The investigators also want to see if Stage and Grade of the periodontal disease has a significant impact on disease progression. In addition, another purpose is to identify factors explaining why certain young patients with periodontitis interrupt the periodontal treatment.
The specific aims of the project are:
- To study the periodontal status and the degree of disease progression over 10 years for young individuals with periodontitis at age < 36 yrs at baseline (study 1)
- To identify factors with a significant influence on periodontitis progression for young individuals with periodontitis at baseline (study 2)
- To identify explanatory factors to discontinuation of periodontal treatment (study 3)
- To identify bio marker and microbiological profiles in young individuals in relation to stage and grade of periodontitis (study 4)
Significance:
A high patient compliance rate and effective supportive treatment to prevent periodontitis progression are crucial conditions for the long-term prognosis. The identification of factors influencing the compliance rate can improve the frequency of individuals following a supportive care program. In addition, long-time follow-up studies of individuals with the diagnosis severe periodontitis at young age are lacking as well as deeper knowledge concerning risk predictors for further disease progression.
The identification of biomarkers or microorganisms that can differentiate between different stage and grade of periodontitis could make it possible to identify individuals with a high risk for disease progression at an early stage.
详细描述
Data collection:
All patients at age <36 years who were examined by a periodontist at 2 specialist clinics in Periodontology (Folktandvården Stockholm) during the years 2003-2009 with the diagnoses aggressive or chronic periodontitis are included in the project. The material consists of 471 patients. All participants are invited by mail to a clinical and radiographic examination. The clinical examination includes periodontal status and microbiological sampling and samples of crevicular fluid from deepened periodontal pockets >6. At time of examination the participants also fill in an questionnaire regarding oral hygiene habits, socio-economic factors and self-percieved oral health. Baseline information is collected from dental records.
Studies 1 and 2:
Title study 1: Periodontal status and disease progression after 10 years in young individuals with periodontitis. A follow-up study.
Title study 2: Risk predictors for periodontitis progression in young individuals with periodontitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with diagnoses aggressive or chronic periodontitis
排除标准
- •Not living in Stockholm County
- •Mental illness.
结局指标
主要结局
Periodontal disease progression in young individuals with periodontitis 10-13 years after baseline
时间窗: October 2018 to May 2021
Periodontal progression will be assessed by Periodontitis grade according to The 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions: This is a categorical variable consisting of ordinal data at three levels (A, B, C). A is the lowest progression rate and C is the highest rate. The assessment is performed by comparing the degree of periodontal bone loss between baseline and follow-up.
次要结局
- Factors influencing tooth loss over 9 - 11 years in young individuals with periodontitis(2020 to 2022)
- To identify bio marker and microbiological profiles in young individuals in relation to stage and grade of periodontitis(2020-2023)
研究者
Carolina Modin
DDS, Senior Consultant in Periodontology
Folktandvården Stockholms län AB