Role of the MET Oncogene in Human Colorectal Cancer. Possible Implications in the Activation of an Acquired Pro-thrombotic Condition - A Translational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Scoring MET expression in colorectal tissue sections by immunohistochemical analysis
研究概览
简要总结
The MET oncogene is known to sustain the Trousseau's syndrome in murine experimental models, featuring association of carcinogenesis with a blood procoagulant disorder. MET is frequently overexpressed in colorectal cancer, a tumor where venous thromboembolism (VTE) may occur in association with poor prognosis, but the biological and genetic factors that cause VTE are still obscure.
The Investigators propose to study whether in patients harboring a surgically resectable colorectal cancer the MET oncogene is expressed and may be associated with a blood thrombophilic condition that favors the onset of VTE.
These data would have two main implications: (i) for the first time, a direct genetic link between the MET oncogene and a procoagulant disorder would be demonstrated in humans; (ii) the procoagulant alterations would have diagnostic/prognostic significance for the identification of patients at risk for poor outcome, and implementation of appropriate therapeutic protocols.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > or = 18;
- •age < or = 80;
- •Clinical diagnosis of colorectal tumor by CT, MRI or endoscopy;
- •surgically resectable tumor;
排除标准
- •Inclusion in other clinical protocols requiring administration of anticoagulant drugs;
- •Life expectancy < 6 month;
- •Clinical diagnosis of thrombophilic condition by laboratory analysis;
- •Previously implanted Central Venous Catheter;
- •Previous or concomitant second neoplasia;
- •Clinical diagnosis of kidney, liver or heart failure;
- •Inflammatory markers alteration associated with disease unrelated to neoplasia (infection, connective tissue disease etc);
- •Severe hemostasis disorder;
结局指标
主要结局
Scoring MET expression in colorectal tissue sections by immunohistochemical analysis
时间窗: After surgical resection of the tumor, approximately 3-5 days after enrollement
Scoring the expression of Plasminogen Activator Inhibitor -1 in colorectal cancer tissue sections by Immunohistochemical analysis
时间窗: After surgical resection of the tumor, approximately 3-5 days after enrollement
Scoring the expression of COX-2 in colorectal cancer tissue sections by Immunohistochemical analysis
时间窗: After surgical resection of the tumor, approximately 3-5 days after enrollement
次要结局
未报告次要终点