ate LTP-like plasticity effects of tDCS in subacute stroke patients

• Conditions: Stroke; 10007963; Cerebrovascular accident

• Registration Number: NL-OMON40946
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

• Subacute stroke (within 1-3 weeks post stroke)
• Acute hemiparesis with single thromboembolic non-hemorrhagic infarction documented by a neurologist
• Aged 18-79

Exclusion Criteria

• Absence of recordable MEPs from the ADM after TMS
• Absence of voluntary movement (MRC < 2)
• Head injury or the presence of intracranial metal or intracranial lesions
• History of cranial irradiation
• History of epilepsy
• Presence of a pacemaker
• Taking anticonvulsant or neuroleptic medication
• Substance abuse
• Inability to understand instructions
• History of psychiatric disorders

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To investigate whether late LTP-like plasticity tDCS increases the<br /><br>effectiveness of upper limb rehabilitation therapy after stroke.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• To investigate whether the application of tDCS in subacute stroke patients<br /><br>increases quality of life, cognitive performance and depression.<br /><br>• To investigate whether late LTP-like plasticity tDCS increases the<br /><br>effectiveness of lower limb rehabilitation therapy after stroke.<br /><br>• To investigate the safety, side effects and drop-out rates for tDCS as an<br /><br>integral part of upper limb rehabilitation in the first months post stroke.</p><br>