Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma

• Conditions: Secondary Open Angle Glaucoma; Primary Open Angle Glaucoma; Ocular Hypertension

• Registration Number: NCT00494923
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991. The primary aim is the evaluation of diagnostic and prognostic validity of morphometrical, sensory and hemodynamical diagnostic procedures. No therapeutic studies are performed.

Detailed Description

Purpose: Detection of onset and progression of structural and functional damage due to glaucoma. Determination of rate and amount of progressive change due to glaucoma. Characterisation of the relationship between structural and functional change over time. Evaluation of predictive factors for the development and progression of glaucoma.

Study Timeline

• Study Start: 1999-01
• Study First Submitted: 2007-06-29
• Study First Submitted QC: 2007-06-29
• Study First Posted: 2007-07-02
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-11
• Last Update Posted: 2013-12-12
• Primary Completion: 2015-12
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2500

Inclusion Criteria

• Open anterior chamber angle
• Best corrected visual acuity 0.7 or better
• Age between 18 and 65 years

Exclusion Criteria

• Any eye disease other than glaucoma
• Systemic diseases with potentially ocular involvement (e.g., diabetes mellitus)
• Myopic or hyperopic refractive error exceeding 8.0 diopters

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to Disease Progression	up to 20 years

Trial Locations

Locations (1)

University Eye Hospital; 🇩🇪 Erlangen, Germany