Reduction of complications for head and neck cancer: Individual lymph node irradiation (iNode)

Recruiting

• Conditions: Head and neck cancer / tumor; 10014713

• Registration Number: NL-OMON51653
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Squamous cell carcinoma of the larynx, oropharynx or hypopharynx
- T2 -T4 stage
- N0-1, based on bilateral ultrasound / MRI / PET of the neck
- Indication for curative primary (accelerated) RT
- Indication for bilateral ENI

Exclusion Criteria

- Concurrent chemotherapy or cetuximab
- Patients unsuited for MRI imaging
- Synchronous malignant tumor(s) at another site
- Previous malignancies in the HN region treated with surgery, chemotherapy or
radiotherapy, except for tumors treated with endoscopic glottic laser
microsurgery.
- Previous dissection of LNs in the neck
- A history of malignant disease for which treatment was ended < 2 year before
diagnosis of the HNSCC, except basal cell carcinoma
- Age <18 years
- WHO performance status: >= 2
- Distant metastasis
- Participation into another interventional study
- Mental or physical impairment causing the participant to be unable to fill
out questionnaires

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The percentage of fractions successfully performed on the MR-Linac. Either<br /><br>inadequate patient tolerability or planning/contouring issues could lead to<br /><br>missing fractions.</p><br>