GABA and Beta-cell Regeneration
- Registration Number
- NCT04375020
- Lead Sponsor
- Ministry of Health and Population, Egypt
- Brief Summary
GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.
- Detailed Description
100 patients with type I diabetes were in 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients.
All the patients Lied between 18-25 years old with 5-10 years of diabetes onset.
The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.
The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily.
In the first group;the investigator measured fasting c peptide levels before and after 6 months of GABA 750mg daily.Also,the investigator measured anti gad antibodies before and after 6 months of treatment.
In the second group,the investigator measured c peptide levels and anti-gad antibodies at the beginning of the trial and after 6 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- type 1 diabetes patients age from 18 to 25 years on basal bolus insulin
thyroid problems liver disease kidney disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description group1 on GABA GABA The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.
- Primary Outcome Measures
Name Time Method gaba decrease anti gad antibodies 6 months gaba 750 mg daily for type 1 diabetes patients
gaba improve c peptide levels 6 months gaba 750 mg pe day for type 1 diabetes patients
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mahmoud Younis
🇪🇬Cairo, Egypt