myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies

Not Applicable

Completed

• Conditions: Polymyositis; Dermatomyositis

• Registration Number: NCT00213629
• Lead Sponsor: University Hospital, Rouen

Brief Summary

The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care.

Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies.

Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-11
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-21
• Primary Completion: 2010-07
• Study Completion: 2010-07
• Status Verified: 2012-02
• Last Update Submitted: 2012-02-14
• Last Update Posted: 2012-02-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• indication of muscle biopsy for diagnostic purpose
• written informed consent

Exclusion Criteria

• vasculitis
• coagulation disorder, impossibility to perform muscle biopsy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
transcriptome	at inclusion

Trial Locations

Locations (1)

University Hospital of Rouen; 🇫🇷 Rouen, Seine Maritime, France