NCT03228693已完成不适用
Gene Expression and Biomarker Profiling of Keloid Skin
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Keloid progression
研究概览
简要总结
This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation.
Hypothesis:
- Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's propensity to develop keloids
- Differences in biomolecules expressed in subjects with and without keloids can help predict keloid occurrence and severity
- Biomarker analysis will provide useful insights for future targeted therapies for keloid scars
详细描述
Objectives:
- Determine gene expression profiles of keloid scar tissue using samples collected longitudinally
- Define and compare the molecular biomarkers of keloid scars in keloid (lesional) and non-lesional skin biopsies and serum samples from adult subjects
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient with an untreated keloid scar or a patient with a keloid scar that has not had treatment for at least 6 months before time of enrollment
- •Patients without keloids coming into the dermatology clinic for a keloid unrelated issue (Group 5 only)
排除标准
- •Patients who have had treatment of their keloid scar within 6 months of date of enrollment
结局指标
主要结局
Keloid progression
时间窗: One year
Assess effectiveness of triamcinolone injection (keloid size measured in millimeters)
Gene Expression
时间窗: One year
Blood will be drawn during first study visit for analysis
Keloid recurrence
时间窗: One year
Assess keloid recurrence at biopsy site (measured by number of keloids)
次要结局
未报告次要终点
研究者
Roopal Kundu
Associate Professor of Dermatology and Medical Education
Northwestern University
研究点 (2)
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