Effectiveness of Antidiabetic Treatment Applied in Childhood Obesity
- Registration Number
- NCT06266598
- Lead Sponsor
- HÜMEYRA ACIKAN
- Brief Summary
In our study, there are 33 healthy children with normal weight (control group) and 52 obese children who will be treated with metformin. To observe the efficacy of the 3-month treatment before and after metformin treatment, Zn, Zinc α-2 Glycoprotein (ZAG), Peroxisome proliferation activating receptor γ (PPARγ), Leptin (LEP) and Adiponectin (ADIPO) levels were compared, as well as anthropometric measurements and routine biochemistry tests.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description obesity Metformin Children with obesity were recommended to have a diet appropriate for their age and gender and exercise at least 3 days a week for at least 60 minutes each time. All obese children under the age of 14 were started on metformin treatment at 1000 mg (500 mgx2) per day, and children over this age were started on metformin treatment at the adult dose of 2000 mg (1000 mgx2) per day.
- Primary Outcome Measures
Name Time Method Insulin resistance (HOMA-IR) level three months HOMA-IR is a condition in which the body's cells become less responsive to the effects of insulin. This means that the body needs more insulin to achieve the same effects, such as regulating blood sugar levels
Weight loss rate three months Weight loss rate is typically defined as the amount of weight lost over a specific period of time.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Erciyes University
🇹🇷Kayseri̇, Melikgazi, Turkey