Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 125
- 试验地点
- 2
- 主要终点
- Change in subjective states (stress, anxiety, positive affect)
研究概览
简要总结
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults who are relatively healthy and aged 21-70 years.
- •Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
- •Must either (1) use CBD daily/regularly or (2) not use CBD regularly.
排除标准
- •Participated in previous acute stress studies that included a similar stress induction.
- •Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
- •Self-reported current pregnancy.
- •Self-reported current use of illicit substances (other than cannabis).
- •Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
- •Students of the principal researcher
研究组 & 干预措施
Experimental group
Participants will include CBD users and non users
干预措施: Stress Intervention (Other)
结局指标
主要结局
Change in subjective states (stress, anxiety, positive affect)
时间窗: 2.5 hours
Participants will self-report the extent to which they have felt stressed, overwhelmed, anxious/nervous, cheerful, and happy during the last 30 minutes before acute stress, immediately after acute stress, and after a recovery period. The Subjective States Questionnaire will be used to score responses. The minimum values are 0 (not at all) and the maximum values are 7 (very strongly). Higher scores mean more stress, more anxiety, and more positive affect.
Change in cardiovascular activity and cortisol
时间窗: 2.5 hours
Saliva will be collected (for later cortisol assays) and cardiovascular activity will be measured before, during, and after acute stress.
次要结局
未报告次要终点