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Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2

Terminated
Conditions
Chronic Periodontitis
Diabetes Type 2
Registration Number
NCT02589314
Lead Sponsor
University of Brasilia
Brief Summary

This study will evaluate if periodontal mechanical treatment is capable to alter immunological and genetical parameters related to systemic health in patients with chronic periodontitis ant diabetes type 2.

Detailed Description

Not available

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
90
Inclusion Criteria

Periodontitis group:

  • Minimum of 15 teeh;
  • At least 30% of sites with periodontal probing depth ≥ 4 mm and at least two teeth with CAL ≥ 3 mm; Age ≥30 years;

Control group:

  • Systemically healthy;
  • 20 teeth;
  • Probing depth ≤3 mm, clinical attachment level ≤3 mm , ≤10% of sites with bleeding on probing.
Exclusion Criteria
  • Periodontal treatment in the last six months;
  • Continued use of medications such as antibiotics, immunomodulatory, anti-inflammatory drugs or corticosteroids in the last three months;
  • Systemic diseases that interfere with periodontal condition, except for diabetes for the test group (HIV, cancer, immune disorders, acute infections, severe allergies, gastrointestinal or kidney disease, morbid obesity [BMI 40 kg / m2] or underweight [evil nourished BMI <18.5 kg / m2], etc.); Pregnant or lactating; smoking; Age <30 years; Indigenous groups.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Evidence of alteration in periodontal pathogens by PCROne year

Evaluate wich periodontal pathogens are detected before and after treatment

Evidence of alteration of immunocellular response by flowcytometryone year

Fenotype Monocytes, PMN, NK cells, T cells, B cells before and after periodontal treatment

Evidence of alteration on pro and anti-inflammatory cytokines by CBAOne year

Dosage of cytokines before and after periodontal treatment

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Priscilla Farias Naiff

🇧🇷

Brasilia, Distrito Federal, Brazil

Priscilla Farias Naiff
🇧🇷Brasilia, Distrito Federal, Brazil

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