Impact of Early Mobilization on Sepsis Patients: influence of Passive and Active Exercises on the cardiovascular and inflammatory systems

Not Applicable

Recruiting

• Conditions: A41.9; Sepsis, endothelium, autonomic nervous system, inflammation

• Registration Number: RBR-7szm34
• Lead Sponsor: Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-08-06
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Clinical diagnosis of sepsis.

Exclusion Criteria

atrial fibrillation;pre-existing atrioventricular block or ventricular tachycardia; recent myocardial infarction (<6 months);patients with pacemaker; stroke; signs of intracranial hypertension; cranioencephalic trauma; neuromuscular disease; Body mass index (BMI) greater than 40; patient with neoplasia undergoing chemotherapy and unconsolidated fracture.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increase in endothelial function, verified by the measurement of vasodilatation mediated by the flow of the brachial artery (FMD) from the difference between basal diameter and hyperemia diameter in percentage.

Secondary Outcome Measures

Name	Time	Method
Increase in cardiac modulation, assessed by increasing heart rate variability (HRV)<br>and their variables, increse in mean RR (mean RR), standard deviation of the mean of all RR-R (STDRR), and square root mean squares of the differences between successive iR-Rs (rMSSD), low frequency indexes - BF and high frequency - AF, in standard units and BF / AF ratio.