Reduction of Obesity-Associated Intestinal Inflammation by Low-Fat Dairy Yogurt
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 128
- 试验地点
- 2
- 主要终点
- Plasma soluble cluster of differentiation 14 (sCD14)
研究概览
简要总结
The main objective of this work is to conduct a clinical trial in obese and non-obese individuals testing the ability of low-fat dairy yogurt to improve gastrointestinal health and reduce chronic inflammation. Our central hypothesis is that short and long-term consumption of low-fat dairy yogurt will reduce inflammation to a greater extent in obese individuals by improving intestinal barrier function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •premenopausal women
- •BMI from 18.5-27 and 30-40 kg/m2
- •resting blood pressure <140/90 mmHg
- •not taking medication to control hypertension
- •stable body weight for the previous 2 months
- •willing to maintain a normal exercise level and avoid exercise 24 h prior to blood sampling
- •willing to avoid yogurt and probiotic-containing foods or consume 2 servings of yogurt for the duration of the study
排除标准
- •previous diagnoses of cardiovascular disease (CVD), diabetes, or arthritis (except for osteo-arthritis)
- •currently being treated for cancer (i.e., chemotherapy, radiation therapy)
- •prescribed estrogen replacement therapy
- •practicing weight-loss, vegetarian, kosher, or vegan diets
- •currently taking dietary supplements
- •exceed alcohol consumption more than moderate drinking (1 drink/day or a total of 7/week)
- •actively using antibiotics
- •taking anti-inflammatory drugs
- •have allergies to soy, egg or milk
- •perimenopausal or menopausal symptoms
研究组 & 干预措施
Non-obese individuals
Daily consumption of 12 oz lowfat yogurt or soy pudding for 9 weeks.
干预措施: Low fat dairy yogurt (Other)
Non-obese individuals
Daily consumption of 12 oz lowfat yogurt or soy pudding for 9 weeks.
干预措施: Soy pudding (Other)
Obese individuals
Consumption of 12 oz of soy pudding or low fat dairy yogurt daily for 9 weeks.
干预措施: Low fat dairy yogurt (Other)
Obese individuals
Consumption of 12 oz of soy pudding or low fat dairy yogurt daily for 9 weeks.
干预措施: Soy pudding (Other)
结局指标
主要结局
Plasma soluble cluster of differentiation 14 (sCD14)
时间窗: 0, 3, 6, and 9 wk
Fasting plasma sCD14 (change from baseline)
次要结局
- Fasting plasma interleukin-6 (IL-6)(0, 3, 6, 9 wk)
- Postprandial sCD14(0 and 9 wk)
- Postprandial interleukin-6 (IL-6)(0 and 9 wk)