Role Of p16 and Ki-67 Immunocytochemistry along with HPV testing in Cervical Epithelial Abnormalities
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The main goal is to find out how accurately p16 Ki-67 and HPV testing can help detect and confirm early changes or abnormal changes of cancer of cervix when compared to standard histopathological examination
研究概览
简要总结
Cervical cancer is a common cancer among women in India, and early detection through screening can greatly reduce deaths. However, routine screening tests like Pap smear and HPV testing have limitations and may lead to unnecessary biopsies. This study aims to evaluate the role of additional biomarkers, p16 and Ki-67, using immunocytochemistry along with HPV testing, in detecting cervical epithelial abnormalities. Since p16 indicates HPV-related cell changes and Ki-67 shows cell proliferation, their combined use may improve diagnostic accuracy. The results will be correlated with histopathology, which is considered the gold standard.
Purpose:The purpose of this study is to find out whether p16 and Ki-67 tests, when used along with HPV testing, can improve the diagnosis of cervical epithelial abnormalities. This will help in better identification of serious lesions, reduce unnecessary biopsies, and improve patient management.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 21.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- Female
入选标准
- •Newly diagnosed cases of cervical epithelial abnormalities.
排除标准
- •Cases of cervical infections and inflammatory lesions.Recurrent cases of cervical epithelial abnormalities.Age less than 21 years.
结局指标
主要结局
The main goal is to find out how accurately p16 Ki-67 and HPV testing can help detect and confirm early changes or abnormal changes of cancer of cervix when compared to standard histopathological examination
时间窗: Baseline
次要结局
- p16 and Ki-67 expression and HPV testing in different categories of cervical epithelial abnormalities as per The Bethseda System.(Baseline)
研究者
Dr Prachi Prajapati
Maulana Azad Medical College