ACTRN12622001444774已完成未知
Effect of potassium bicarbonate supplementation on myofibrillar protein synthesis in older women
Dr Caoileann Murphy0 个研究点目标入组 20 人开始时间: 2022年11月11日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 65 Years 至 90 Years（—）
- 性别
- Female
入选标准
- •Women aged between 65 and 90 y
- •- 24-h urine pH of less than or equal to 6.7 at screening
排除标准
- •Self-reported history of conditions impacting acid-base balance (i.e. renal disease, addison’s disease, severe COPD with CO2 retention, kidney stones in last 2 years, liver cirrhosis), active hyperparathyroidism, untreated thyroid disease, significant immune disorders, unstable heart disease, primary aldosteronism, active malignancy, type 1 diabetes mellitus, active inflammatory bowel disease, neuromuscular disease (e.g. Myasthenia gravis, MS, muscular dystrophies, MND), Parkinson’s disease
- •Medications that can impact acid-base balance, skeletal muscle / bone turnover (i.e. current use of diuretics, antacids containing aluminum hydroxide or magnesium hydroxide), HRT, insulin, drugs affecting bone turnover (bisphosphonates or denosumab in the last year, other osteoporosis medications [Tamoxifen/raloxifene, calcitonin, oestrogen] in the last 3 months, glucocorticoids for >10 days in the last 3 months), simvastatin / zocor, oestrogen suppressants , warfarin, anticoagulants other than aspirin (will be stopped 3 days prior to each biopsy)
- •Glomerular filtration rate (GFR) <51 mL/min/1.73m2 and a serum potassium >5.3 mmol/L (assessed during participant screening)
- •Regular resistance structured training (> 1 sessions of structured training / week)
- •Participants taking nutritional supplements will be asked to cease taking these 2 weeks prior to, and for the duration of the study, including potassium-containing salt substitutes
- •Total walking incapacity
- •Women must be at least 1 year since last menses
- •Bone mineral density (BMD) T-score below -2.5 at the lumbar spine or total hip
- •Cachexia – defined as unintentional weight loss > 5% in last 6 months or, in persons with BMI < 20 kg/m2 weight loss > 2%, or low muscle mass (ASMI < 7 kg/m2 in men, < 5.5 kg/m2 in women) plus > 2% weight loss in individuals with an underlying condition associated with cachexia
- •Current infectious disease or diagnosis of bloodborne disease
- •Allergy to local anaesthesia
- •Mini Mental State Examination (MMSE) score < 24
- •If participant’s GP reports they have an excluded condition or are taking an excluded medication
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