Improving Metabolism With HDL Cholesterol

Not Applicable

Completed

• Conditions: Heart Disease; Diabetes

• Registration Number: NCT00395148
• Lead Sponsor: Bayside Health

Brief Summary

High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-03
• Status Verified: 2006-10
• Study First Submitted: 2006-10-31
• Study First Submitted QC: 2006-10-31
• Study First Posted: 2006-11-02
• Primary Completion: 2008-03
• Study Completion: 2008-03
• Last Update Submitted: 2011-05-09
• Last Update Posted: 2011-05-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 13

Inclusion Criteria

• Aged 18 - 65 years
• Free of overt coronary disease
• Body mass index <35 kg.m-2
• Fasting plasma glucose > 7 mmol/L-1
• No major illness

Exclusion Criteria

• Unable to give informed consent
• Smokers
• Abnormal LFT, U&E, FBE or creatinine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Metabolic parameters

Trial Locations

Locations (1)

Alfred Hospital; 🇦🇺 Melbourne, Victoria, Australia