Characterization of functionality of HDL in patients with familial hypercholesterolemia

Completed

• Conditions: 10014699; 10013317; 10003216

• Registration Number: NL-OMON29851
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 36

Inclusion Criteria

Diagnosis of Familial Hypercholesterolemia, age between 18 en 70 years, LDL-cholesterol level>200mg/dl, triglyceride-level<150mg/dl

Exclusion Criteria

Type 2 diabetes mellitus, presence of inflammatory or infectious diseases, acute myocardial infarction or stroke during last six months, smoking, use of anti-inflammatory drugs (except aspirin) or anti-oxidant vitamins during last month

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Compositional and structural properties of HDL subfractions as well as their<br /><br>protective activity towards LDL oxidation will be characterised.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>