Impact of IDH Mutation and Adjuvant Chemo(radio)therapy on Survival Outcome in Grade II/III Astrocytoma

Completed

• Conditions: Astrocytoma; Astrocytic Tumors; Astrocytoma of Brain
• Interventions: Other: IDH mutant-type; Other: IDH wild-type

• Registration Number: NCT06620926
• Lead Sponsor: asmaa salama ibrahim

Brief Summary

This study looked at a type of brain tumor called astrocytoma and how specific genetic changes like IDH mutations affect patients outcomes. Recent studies found that people with IDH-mutated astrocytomas tend to live longer and have better survival rates compared to those without these mutations. One reason for this is that IDH-mutated tumors usually grow more slowly and are less aggressive. These findings suggest that testing for IDH mutations could help doctors make more personalized treatment plans for patients, which may lead to better results. However, larger studies are needed to confirm these observations. the investigators used the Surveillance, Epidemiology and End Results (SEER) database to obtain the data of 811 patients with grade II/III astrocytoma. The data are publicly available and no consent or ethical approval is needed for this study. The clinicopathological data of patients, including the age, gender, race, IDH status (mutant/wild), astrocytoma type (diffuse/anaplastic), surgery (tumor destruction, Local excision, partial, radical, total gross resection, Surgery), radiation (Beam radiation, Radioactive implants including brachytherapy, Radioisotopes, Combination of beam with implants or isotopes, Radiation, method or source not specified), chemotherapy, vital status, and survival months, were extracted. Patients were sub-grouped according to the IDH type into IDH mutant-type and wild-type. with further stratification according to the treatment modality into three groups: adjuvant chemotherapy, adjuvant radiotherapy, and combined adjuvant chemoradiotherapy. The Observed survival and cause-specific survival were calculated using SEER\*stat software version 8.4.3 and SPSS version 25 was used for survival analysis. Significance was achieved at 0.05.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2020-12-30
• Study Completion: 2021-12-30
• Study First Submitted: 2024-09-28
• Study First Submitted QC: 2024-09-28
• Status Verified: 2024-10
• Study First Posted: 2024-10-01
• Last Update Submitted: 2024-10-25
• Last Update Posted: 2024-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 811

Inclusion Criteria

• Patients were selected only if they had astrocytoma with malignant behavior
• Grade II-III astrocytoma
• First primary tumor with sequence 0 or 1
• Had surgical intervention (tumor destruction, Local excision, partial, radical, total gross resection, Surgery)

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Exclusion Criteria

• unknown survival time
• patients with unknown age
• death certificate only and autopsy only cases

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients having astrocytoma with IDH mutant-type	IDH mutant-type	-
Patients having astrocytoma with IDH wild-type	IDH wild-type	-

Primary Outcome Measures

Name	Time	Method
The 2-year relative survival and 2-year observed survival of grade II/III astrocytoma with IDH mutation	from Jan, 2018 till Dec, 2020

Secondary Outcome Measures

Name	Time	Method
The 2-year relative survival of different treatment with modalities chemo(radio)therapy among both groups: IDH wild type and IDH mutant type astrocytoma	Jan, 2018 till Dec, 2020

Trial Locations

Locations (1)

Suez Canal University; 🇪🇬 Ismailia, Egypt