Determining the effect of Ketemine on the treatment resistant depressio

Phase 1

Recruiting

• Conditions: Major Depressive Disorder.; Major depressive disorder, recurrent, unspecified; F33.9

• Registration Number: IRCT20210806052096N1
• Lead Sponsor: Zanjan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 May 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Diagnosis of major depressive disorder based on DSMV criteria
Failure to respond to at least 2 antidepressants with sufficient therapeutic dose
The criterion of Montgomery-Asberg at least 25

Exclusion Criteria

Having skull masses
Having history of HTN
Having history of IHD
Having a recent or past psychotic disorder
Consumption of recent substances
Pregnancy
Existence of unstable medical disease

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression severity based on Montgomery-Asberg. Timepoint: Before injecting the drug-Immediately after drug injection-1 hour after drug injection-4 hour after drug injection-1 day after drug injection-3 day after drug injection-7 day after drug injection-1 month after drug injection-2 month after drug injection. Method of measurement: Based on Montgomery-Asberg questionnaire.

Secondary Outcome Measures

Name	Time	Method
Suicide idea. Timepoint: Before the drug injection-after the drug injection. Method of measurement: Based on the Beck questionnaire.