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Clinical Trials/NCT01228123
NCT01228123CompletedPhase 2

Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients

Charite University, Berlin, Germany2 sites in 1 country252 target enrollmentStarted: January 2002Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Phase 2
Status
Completed
Enrollment
252
Locations
2
Primary Endpoint
Survival at 2 weeks after RRT

Study Overview

Brief Summary

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Detailed Description

please see above

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Diagnostic
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • all ICU patients requiring renal replacement therapy

Exclusion Criteria

  • patient denies informed consent
  • patient not requiring intensive care therapy
  • kidney transplanted patients
  • chronic renal failure (serum creatinine > 3mg/dl)

Arms & Interventions

CVVH arm

Active Comparator

Intervention: RRT for acute kidney failure using the CVVH method (Other)

IHD arm

Active Comparator

Intervention: RRT for acute kidney failure using the IHD (intermittent HD) (Other)

Outcomes

Primary Outcomes

Survival at 2 weeks after RRT

Time Frame: 2 weeks after RRT in follow-up

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other

Study Sites (2)

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