Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients

Phase 2

Completed

• Conditions: Acute Renal Failure
• Interventions: Other: RRT for acute kidney failure using the CVVH method; Other: RRT for acute kidney failure using the IHD (intermittent HD)

• Registration Number: NCT01228123
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Detailed Description

please see above

Study Timeline

• Study Start: 2002-01
• Primary Completion: 2007-10
• Study Completion: 2008-01
• Status Verified: 2010-07
• Study First Submitted: 2010-10-25
• Study First Submitted QC: 2010-10-25
• Study First Posted: 2010-10-26
• Last Update Submitted: 2011-05-23
• Last Update Posted: 2011-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 252

Inclusion Criteria

• all ICU patients requiring renal replacement therapy

Exclusion Criteria

• patient denies informed consent
• patient not requiring intensive care therapy
• kidney transplanted patients
• chronic renal failure (serum creatinine > 3mg/dl)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CVVH arm	RRT for acute kidney failure using the CVVH method	-
IHD arm	RRT for acute kidney failure using the IHD (intermittent HD)	-

Primary Outcome Measures

Name	Time	Method
Survival at 2 weeks after RRT	2 weeks after RRT in follow-up

Trial Locations

Locations (1)

Charite University Medicine; 🇩🇪 Berlin, Germany