Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Enrollment
- 252
- Locations
- 2
- Primary Endpoint
- Survival at 2 weeks after RRT
Study Overview
Brief Summary
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.
Detailed Description
please see above
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •all ICU patients requiring renal replacement therapy
Exclusion Criteria
- •patient denies informed consent
- •patient not requiring intensive care therapy
- •kidney transplanted patients
- •chronic renal failure (serum creatinine > 3mg/dl)
Arms & Interventions
CVVH arm
Intervention: RRT for acute kidney failure using the CVVH method (Other)
IHD arm
Intervention: RRT for acute kidney failure using the IHD (intermittent HD) (Other)
Outcomes
Primary Outcomes
Survival at 2 weeks after RRT
Time Frame: 2 weeks after RRT in follow-up
Secondary Outcomes
No secondary outcomes reported