Effects of SGLT2i on the Cognitive Function in T2DM Patient (ESCDP)
- Conditions
- Diabetes Mellitus, Type 2Cognitive Functions Confusion
- Interventions
- Registration Number
- NCT04304261
- Lead Sponsor
- Third Military Medical University
- Brief Summary
Type 2 diabetes is associated with diabetic cognopathy, the prevalence of Alzheimer's Disease(AD) in T2DM patients is 1.5 to 2.5 times higher than the general population. Cognitive impairment seriously affects the health and quality of life of the elderly. Prevention and treatment measures for cognitive decline in persons with T2DM has not been well studied.
Sodium-glucose transporter-2 (SGLT-2) inhibitors, which lower serum glucose by inhibiting SGLT2-mediated glucose reabsorption in renal proximal tubules, could be neuroprotective. It was recently reported that the SGLT-2 inhibitor improved cognitive function and ameliorated oxidative stress via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in mice or HFD-induced obese rats, that means SGLT-2 inhibitor may provide neuroprotection in the diabetic brain. Hence, Invokana (Canagliflozin) might act as a potent dual inhibitor of AChE and SGLT2. Since the development of diabetes is associated with AD, the design of new AChE inhibitors based on antidiabetic drug scaffolds would be particularly beneficial. Moreover, the present computational study reveals that Invokana (Canagliflozin) is expected to form the basis of a future dual therapy against diabetes associated neurological disorders.
The overall goal of this study is to explore the effects of SGLT2 inhibitor on the cognitive function in patients with type 2 diabetes mellitus and make further contribution to the improvement of cognitive function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Newly onset type 2 diabetes within 3 months
- 7%<HbA1c<10%
- Type 2 diabetes with acute diabetic complications.
- Type1 diabetes.
- Thyroid dysfuncition.
- Any surgical or medical conditions that significantly influence absorption, distribution, metabolism or excretion of the intervention drugs.
- History of cardio-cerebral vascular events, such as congestive heart failure, myocardial infarction or stroke within 3 months.
- Hepatic insufficiency (AST or AST is twice higher than the upper limit) or history of hepatitis or cirrhosis, hepatic encephalopathy.
- Renal insufficiency (serum creatinine 1.5 times higher than the upper limit) or history of dialysis and nephritic syndrome.
- Acute infections, tumor, severe arrhythmia.
- Alcohol or medicine addiction, psychoactive substance abuse.
- Other diseases affecting cognitive function (congenital dementia, brain trauma, parkinson's diseases, toxicencephacopathy,epilepsy, mental disorders, severe lungdy sfunction, epilepsy, severe hypoglycemic coma, cerebrovascular disease, ischemic heart disease, etc.)
- Fertile woman without contraceptives.
- Allergic to or have contraindication to the intervention drugs.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Canagliflozin Canagliflozin 12 weeks of Canagliflozin(100mg/day) treatment, randomly Sitagliptin Sitagliptin 12 weeks of Sitagliptin (100mg/day) treatment, randomly
- Primary Outcome Measures
Name Time Method Changes of cognitive function assessed by cognitive function scale 12 weeks cognitive function scale
- Secondary Outcome Measures
Name Time Method Changes of standardized uptake values of brain and splanchnic organs assessed by 18F-PET-CT 1 week 18F-PET-CT
Changes of brain function assessed by near infrared brain functional imaging 4 week near infrared brain functional imaging
Changes of urinary sodium and glucose excretion (mmol/24h) 1 week urinary sodium and glucose excretion
Trial Locations
- Locations (1)
Zhiming Zhu
🇨🇳Chongqing, Chongqing, China