Pharmacokinetic/Pharmacodynamic Parameters Associated With the Emergence of Resistance to Ciprofloxacin in Human Commensal Flora

Assistance Publique - Hôpitaux de Paris1 site in 1 country48 target enrollmentSeptember 2004

ConditionsHealthy Volunteers

Drugsciprofloxacin

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy Volunteers
Sponsor: Assistance Publique - Hôpitaux de Paris
Enrollment: 48
Locations: 1
Primary Endpoint: Occurrence of bacterial resistance in commensal flora
Status: Terminated
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Bacterial resistance to antibiotics has been a growing therapeutic problem since the late 1980s. Resistant strains of pathogenic bacteria can arise through initial selection of resistant strains in the commensal flora. The emergence of fluoroquinolone resistance in the commensal flora will be assessed in 48 healthy volunteers receiving variable doses of ciprofloxacin during 14 days. Emergence of resistance will be correlated to pharmacokinetic characteristics of ciprofloxacin.

Detailed Description

Pharmacokinetic/Pharmacodynamic Parameters Associated With the Emergence of Resistance to Ciprofloxacin in Human Commensal Flora Bacterial resistance to antibiotics has been a growing therapeutic problem since the late 1980s. Resistant strains of pathogenic bacteria can arise through initial selection of resistant strains in the commensal flora. The emergence of fluoroquinolone resistance in the commensal flora will be assessed in 48 healthy volunteers receiving variable doses of ciprofloxacin during 14 days. Emergence of resistance will be correlated to pharmacokinetic characteristics of ciprofloxacin.

Registry

clinicaltrials.gov

Start Date

September 2004

End Date

July 2005

Last Updated

13 years ago

Study Type

Interventional

Study Design

Single Group