CTRI/2020/06/025688已完成1 期
Combination of Letrozole and Clomiphene Citrate VersusLetrozole alone for ovulation induction in women with polycystic ovary syndrome-a Randomized Controlled Trial
Dr Anupama Bahadur1 个研究点 分布在 1 个国家目标入组 84 人开始时间: 2020年10月6日最近更新:
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Total number of women attaining clinical pregnancy in either group (confirmed by USG)
研究概览
简要总结
In this trial we are giving Ovulation induction with Letrozole or letrozole+ clomiphene citrate for anovulatory PCOS females with infertility and comparing the pregnancy rate in both groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 38.00 Year(s)（—）
- 性别
- Female
入选标准
- •1-Women 20–35 years of age with PCOS(according to Rotterdam criteria).
- •2-Primary / Secondary Infertile women with PCOS 3-BMI <30 kg/m2 4-Willing to participate in study and follow up.
排除标准
- •1-Pregnancy 2-Patient already on other drugs for treatment of PCOS like OCPs 3-Other known cause of infertility (Endometriosis, Unexplained Infertility, Moderate to severe male factor infertility) 4-Deranged kidney or liver function tests 5-Uncontrolled Thyroid disorders 6-Untreated hyperprolactinemia 7-Women with any other endocrinological disorders 8-Medical conditions not well controlled or not recommended during pregnancy (i.e., uncontrolled type 1 or 2 diabetes mellitus, hypertension, hypothyroidism) 9-Allergy or contraindications to letrozole or CC 10-Clinical suspicion of other etiologies that mimic PCOS warranting additional evaluation.
结局指标
主要结局
Total number of women attaining clinical pregnancy in either group (confirmed by USG)
时间窗: 18 months
次要结局
- 1.Ovulation rate(2.Number of OHSS(Ovarian Hyper-Stimulation Syndrome) cases)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
3 期
The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)Polycystic Ovarian SyndromeNCT01577017Nik Hazlina150
Unknown
不适用
Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo TransferFemale Infertility Due to Nonimplantation of OvumNCT02775877Navy General Hospital, Beijing100
已完成
不适用
Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian SyndromePolycystic Ovary SyndromeNCT05075863Nishtar Medical University78
招募中
不适用
LE + CC vs. LE for Ovulation InductionNCT06934785Mỹ Đức Hospital600
已完成
4 期
Letrozole Versus Clomifene Citrate for Ovulation InductionPolycystic Ovarian SyndromeInfertilityNCT00478504University of Nottingham159