Serum Biomarkers Associated With Postpartum T2DM in Women With GDM

Completed

• Conditions: Gestational Diabetes

• Registration Number: NCT04539288
• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Brief Summary

Gestational diabetes mellitus (GDM) is commonly linked to the development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with GDM in order to find novel biomarkers for T2DM.

Detailed Description

GDM, a common complication of pregnancy, affects 17.8% of pregnancies worldwide per year. Women with a history of GDM have an approximately 7-fold higher risk for developing T2DM in the future than women without GDM. However, data on the factors associated with the development of T2DM in women with GDM are not widely available.

Study Timeline

• Study Start: 2013-05-01
• Primary Completion: 2018-05-30
• Study Completion: 2018-05-30
• Study First Submitted: 2018-09-05
• Status Verified: 2020-09
• Study First Submitted QC: 2020-09-01
• Last Update Submitted: 2020-09-03
• Study First Posted: 2020-09-04
• Last Update Posted: 2020-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 3099

Inclusion Criteria

• Women who were dignosed GDM.
• Women with singleton pregnancy.
• Give birth in the First Affiliated Hospital in Sun Yat-sen University.

Exclusion Criteria

• Women who were diagnosed PGDM.
• Younger than 18 years old.
• Older than 45 years old.
• Multiple pregnancy.
• Diagnosed DM before.
• Complicationg other diseases, like hypertension, thyroid diseases, etc.
• Taking any drug affect glucose and lipid metabolism.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
T2DM	4-6 weeks.	Women with GDM develop T2DM in postpartum.

Secondary Outcome Measures

Name	Time	Method
IGT	4-6 weeks.	Women with GDM were impaired glucose intolerance in postpartum.

Trial Locations

Locations (1)

Obstetrics and Gynechology Department of the 1st affiliated hospital of Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China