Italian Sarcoma Group: non-metastatic OsteoSarcoma 1

Not Applicable

Completed

• Conditions: Osteosarcoma; Cancer; Bone cancer

• Registration Number: ISRCTN21335128
• Lead Sponsor: Orthopaedic Institute Rizzoli (Istituti Ortopedici Rizzoli) (Italy)

Brief Summary

2012 Results article in https://pubmed.ncbi.nlm.nih.gov/22564997/ (added 01/09/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-03-01
• Study Completion: 2006-12-31
• Last Update Posted: 13 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 246

Inclusion Criteria

1. Patients with typical radiographic and histological features of primary, high-grade central osteosarcoma
2. Tumour located in the extremity
3. No previous history of cancer and no prior treatments
4. Aged under 40
5. No co-existing disease contraindicating chemotherapy
6. No evidence of metastases at diagnosis
7. Informed consent

Exclusion Criteria

1. Metastatic osteosarcoma
2. Previous history of cancer
3. Co-existing disease contraindicating chemotherapy
4. No informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical efficacy in terms of event free survival, disease free survival and overall survival.

Secondary Outcome Measures

Name	Time	Method
To compare the toxicity of the two regiments.