Frontal transcranial direct current stimulation (tDCS) as a potential treatment for long-COVID-Fatigue

Not Applicable

• Conditions: ong/Post-COVID patients with cognitive fatigue; U09.9!

• Registration Number: DRKS00031294
• Lead Sponsor: Otto-von-Guericke-Universität Magdeburg, med. Fakultät, Universitätsklinik für Neurologie, Sektion Neuropsychologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-17
• Study Completion: 2023-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

cognitive fatigue (WeiMUS cognitive scale >= 17)
- positive SARS-CoV-2-finding (COVID-19), at least 3 months old

Exclusion Criteria

- diagnose of depression or anxiety disorder, other psychiatric disorders
- medication with antidepressants, opioids, anticonvulsants
- neurological disorders

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement of subjective Fatigue (MFIS; total and subscales) through repetitive verum tDCS<br>Assessment: Three or four days before the first stimulation session (pre), one day after the last stimulation session (post), one month after the last stimulation session (follow-up)

Secondary Outcome Measures

Name	Time	Method
- Improvement of Quality of Life (EQ-5D-5L)<br>- Improvement of subjective state fatigue (VAS)<br>- Improvement of objective fatigability parameters (behavioral data)<br>- Improvement of fatigability associated EEG-components: Alpha, Theta, P50<br>Assessment: Three or four days before the first stimulation session (pre), one day after the last stimulation session (post), one month after the last stimulation session (follow-up)