The Effect of Nighttime Macronutrient Choice and Combined Resistance and High-Intensity Interval Training on Body Composition, Cardiovascular Health, Resting Metabolism, Appetite and Strength in Overweight and Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Body Composition
研究概览
简要总结
Obesity is recognized as a major public health concern because of its link to potential fatal complications arising from metabolic and cardiovascular diseases. Despite many pharmacological advances in this field, lifestyle strategies that emphasize proper nutrient intake and physical activity continue to be the primary strategy for individuals to fight obesity. However, controversy exists regarding the type and timing of exercise and specific nutrient intake to maximize fat loss, muscle gain, and beneficial cardio-metabolic adaptations derived from these lifestyle interventions. Furthermore, limited data exists investigating the impact of nutrient timing at times other than immediately before or after exercise and no studies have examined time-of-day nutritional intake in overweight or obese individuals.In addition, many individuals attempting to improve body composition and cardio-metabolic health are concerned with what food choices are appropriate in the late evening to support positive physiological adaptations. However, research-based information examining this topic is scarce.
The investigators hypothesize that consumption of a protein beverage in the late evening before sleep will improve body composition, cardio-metabolic health, and adaptations to exercise more than an isocaloric placebo beverage. The investigators also hypothesize that the different digestion and absorption kinetics of whey and casein proteins will elicit different effects on the measures variables.
详细描述
The purpose of this study is to examine the effect of consumption of a protein beverage in the late evening before sleep along with the combination of resistance and high-intensity interval training on improving body composition, muscle strength and overall health compared to a carbohydrate placebo beverage in overweight and obese individuals. Specifically, we will be measuring heart rate, blood pressure, body composition, resting metabolism, maximal strength,cardiovascular function, hormones levels, blood lipid profile, appetite, mood state, and dietary intake. Specific aims of the study are:
To determine if acute ingestion of a liquid ready-to-drink protein supplement (30g whey or casein protein per serving) consumed in the late evening before sleep will alter the physiological milieu to favor anabolism and alter lipolysis and fat oxidation more than the carbohydrate placebo (34g of maltodextrin per serving).
To determine if 4 weeks of daily protein supplementation (same supplement as above) in the late evening along with 3 days of exercise training per week will improve body composition, blood lipid profile, strength, cardiovascular risk profile more than a placebo beverage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •Sedentary(exercises <2 days per week for more than 40 minutes per session within the past 6 months)
- •overweight or obese (BMI ≥ 25)
排除标准
- •Those that exercise for more than 2 days per week for more than 40 minutes per session (within the past 6 months),
- •Those that have uncontrolled hypertension (Blood Pressure (BP)>160/100 mmHg)
- •Those that take BP medications
- •Those diagnosed cardiovascular disease
- •Those diagnosed with stroke
- •Those diagnosed with diabetes
- •Those diagnosed with thyroid dysfunction
- •Those diagnosed with kidney dysfunction
- •Those with any musculoskeletal complications that would impede exercise
- •Those that smoke heavily (>20 cigarettes per day)
- •Those that take cholesterol medication
- •Those that take nutritional supplements (except for a multivitamin)
- •Those with any allergies to milk products
研究组 & 干预措施
Whey Protein and Exercise Training
This arm involves 4 weeks of consuming a whey protein supplement late in the evening before bed along with combined resistance and high-intensity interval training 3 days per week for 4 weeks (two days of resistance training and one day of high-intensity interval training).
干预措施: Combined Resistance and High-Intensity Interval training (Other)
Carbohydrate and Exercise Training
This arm involves 4 weeks of consuming a carbohydrate placebo late in the evening before bed along with combined resistance and high-intensity interval training 3 days per week for 4 weeks (two days of resistance training and one day of high-intensity interval training).
干预措施: Combined Resistance and High-Intensity Interval training (Other)
Casein Protein and Exercise Training
This arm involves 4 weeks of consuming a casein protein supplement late in the evening before bed along with combined resistance and high-intensity interval training 3 days per week for 4 weeks (two days of resistance training and one day of high-intensity interval training).
干预措施: Combined Resistance and High-Intensity Interval training (Other)
Casein Protein and Exercise Training
This arm involves 4 weeks of consuming a casein protein supplement late in the evening before bed along with combined resistance and high-intensity interval training 3 days per week for 4 weeks (two days of resistance training and one day of high-intensity interval training).
干预措施: Casein Protein (Other)
Whey Protein and Exercise Training
This arm involves 4 weeks of consuming a whey protein supplement late in the evening before bed along with combined resistance and high-intensity interval training 3 days per week for 4 weeks (two days of resistance training and one day of high-intensity interval training).
干预措施: Whey Protein (Other)
结局指标
主要结局
Body Composition
时间窗: 4 weeks
Measuring fat mass and lean mass from dual-energy x-ray absorptiometry.
Metabolism
时间窗: 4 weeks
Measured using indirect calorimetry, a non-invasive test that involves lying down on a padded table for 30-minutes with a mouth piece and nose clip
次要结局
- Arterial Stiffness(4 weeks)
- Blood biomarkers(4 weeks)
- Appetite(4 weeks)
- Strength(4 weeks)
研究者
Michael J. Ormsbee
Assistant Professor
Florida State University