Cardiac Function and Metabolism in Young Adults Born Premature
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Cardiac Glucose Uptake During Normoxic Rest (µg/Min)
研究概览
简要总结
The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.
详细描述
The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •National Lung Project Cohort only- birth weight <1500g and a gestational age <36 weeks
- •Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
- •Healthy Controls only- No personal history of known cardiovascular or pulmonary disease
排除标准
- •Metabolic Disorders that would affect Fludeoxyglucose uptake
- •Contraindications to positron emission tomography and/or magnetic resonance imaging
- •Pregnancy, if a female of child-bearing potential
- •A personal history of Type I or Type II diabetes
研究组 & 干预措施
Preterm
Participants born premature either registered on the National Lung Project (currently in their late twenties) or not registered on the National Lung Project Cohort (current age ranges 18-35 years).
All the participants in this group will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Pulmonary Function Testing (Procedure)
Preterm
Participants born premature either registered on the National Lung Project (currently in their late twenties) or not registered on the National Lung Project Cohort (current age ranges 18-35 years).
All the participants in this group will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Electrocardiogram (Procedure)
Preterm
Participants born premature either registered on the National Lung Project (currently in their late twenties) or not registered on the National Lung Project Cohort (current age ranges 18-35 years).
All the participants in this group will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Positron Emission Tomography (Procedure)
Preterm
Participants born premature either registered on the National Lung Project (currently in their late twenties) or not registered on the National Lung Project Cohort (current age ranges 18-35 years).
All the participants in this group will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Magnetic Resonance Imaging (Procedure)
Term - Healthy Controls
Healthy individuals that were not born premature. Individuals are ages 18-35. Subjects will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Pulmonary Function Testing (Procedure)
Term - Healthy Controls
Healthy individuals that were not born premature. Individuals are ages 18-35. Subjects will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Electrocardiogram (Procedure)
Term - Healthy Controls
Healthy individuals that were not born premature. Individuals are ages 18-35. Subjects will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Positron Emission Tomography (Procedure)
Term - Healthy Controls
Healthy individuals that were not born premature. Individuals are ages 18-35. Subjects will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.
干预措施: Magnetic Resonance Imaging (Procedure)
结局指标
主要结局
Cardiac Glucose Uptake During Normoxic Rest (µg/Min)
时间窗: Visit 1 (1 day)
Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.
Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min)
时间窗: Visit 1 (1 day)
Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.
次要结局
未报告次要终点